Επιστημονικό Έργο

Οι έρευνες του Dr. Barry Sears 

1. Griffiths, R.R., Sears, B., and Jennings, L.B. “Specificity of transfer of a learned response by intracisternal injection of brain extract from trained rats: negative findings.”Αναφορές για τη φυσιολογία 25: 339348 – (1969)
2. Baumrucker, J., Calzadilla, M., Centeno, M., Lehrmann, G., Linquist, P., Dunham, D., Price, M., Sears, B., and Cordes, E.H. “Secondary valence force catalysis. XI. Enhanced reactivity and affinity of cyanide ions elicted by ionic surfactants.” J Phys Chem 74: 11521156 – (1970)
3. Baumrucker, J., Calzadilla, M., Centeno, M, Lehrmann, G., Urdaneta, M., Linquist, P., Dunham, D., Price, M., Sears, B., and Cordes, E.H. “Secondary valence force catalysis. XII. Enhanced reactivity and affinity of cyanide toward Nsubstituted 3carbomoylpyridinium ions elicted by ionic surfactants and biological lipids.” J Am Chem Soc 94: 81628172 – (1972)
4. Williams, E., Sears, B., Allerhand, A., and Cordes, E.H. “Segmental motion of amphipathic molecules in aqueous solutions and micelles. Applications of natural abundance 13C partially relaxed fourier transform nuclear magnetic resonance spectroscopy. J Am Chem Soc 95: 48714874 – (1973)
5. Sears, B., Hutton, W.C., and Thompson, T.E. “13C NMR studies on bilayers formed from synthetic di10methylstearoyl phosphatidylcholine enriched with 13C in the Nmethyl carbons.” Biochem Biophys Res Comm 60: 1141147 – (1974)
6. Sears, B. “13C Nuclear Magnetic Resonance Studies of Egg Phosphatidylcholine.” J Mem Biol 20: 5973 – (1975)
7. Sears, B., Hutton, W.C., and Thompson, T.E. “Effects of paramagnetic shift reagents on the 13C nuclear magnetic resonance spectra of egg phosphatidylcholine enriched with 13C in the Nmethyl carbons.” Biochemistry 15: 16351639- (1976).
8. Yeagle, P.E., Hutton, W.C., Martin, R.B., Sears, B., and Huang. C. “Transmembrane asymmetry of vesicle lipids.” J Biol Chem 251: 21102114 – (1976)
9. Sears, B., Deckelbaum, R.J., Janiak, M.J., Shipley, G.G., and Small, D.M. “Temperature dependent 13C nuclear magnetic resonance studies of human serum low density lipoproteins.” Biochemistry 15: 41514157 – (1976)
10. Curatolo, W.C., Shipley, G.G., Small, D.M., Sears, B., and Neuringer, L.J. “Effect of lectininduced agglutination on 13C nuclear magnetic resonance line width in sonicated phospholipid/glycolipid vesicles.” J Amer Chem Soc 99: 67716772 – (1977)
11. Roseman, M.A., Lentz, B., Sears, B., Gibbes, D., and Thompson, T.E. “Properties of sonicated vesicles of three synthetic phospholipids.” Chem Phys Lipids 21: 205210 – (1978)
12. Curatolo, W.C., Yau, A.O., Small, D.M., and Sears, B. “Lectininduced agglutination of phospholipid/glycolipid vesicles.” Biochemistry 17: 57405744 – (1978)
13. Neuringer, L.J., Sears, B., and Jungalwala. “Difference in orientational order in phospholipid and sphingomyelin bilayers. FEBS Letters 104: 173175 – (1979)
14. Neuringer, L.J., Sears, B., and Jungalwala, F.B. “2H NMR studies of the interaction of cerebrosides withdipalmitoyl phosphatidylcholine in bilayers.” Biochim Biophys Acta 558: 325329 – (1979)
15. Widder, K.J., Senyei, A.E. and Sears, B. “Experimental methods in cancer therapeutics.” J Pharm Sci 71: 379387 – (1982)
16. Mendelsohn, R., Dluhy, R.A., Curatolo, and Sears, B. “Order and fluidity in terminal methyl regions of dipalmitoyl phosphatidylcholine mutilayers: a comparison of Raman and deuterium NMR spectroscopy.” Chem Phys Lipids 30: 287291 – (1983)
17. Stark, R.E., Manstein, J.L., Curatolo, W.C., and Sears, B. “Deuterium NMR of bile – salt/phosphatidylcholine mixed micelles.” Biochemistry 22: 24862490-(1983)
18. Curatolo, W.C., Sears, B., and Neuringer, L.J. “A calorimetry and deuterium NMR study of mixed model membranes of 1palmitoyl2oleyl phosphatidylcholine and saturated phosphatidylcholines.” Biochim Biophys Acta 817: 261270 – (1985)
19. Curatolo, W.C., Jungalwala, F.B., Sears, B., Tuck, L., and Neuringer, L.J. “Deuterium NMR spectroscopy of biosynthetically deuterated mammalian tissues.” Biochemistry 24: 43604364 – (1985)
20. Sears, B. “Essential fatty acids and dietary endocrinology: a hypothesis for cardiovascular treatment.” J Adv Med 6: 211224 – (1993)
21. Sears, B. “The Zone diet and athletic performance.” Sports Med 99: 289291 – (2000)
22. Bell, S.J. and Sears, B. “Lowglycemic load diets: Impact on obesity and chronic diseases.” Crit Rev Food Sci and Nutr 43(4):357377 – (2003)
23. Bell, S.J. and Sears, B. “A Proposal for a New National Diet: A LowGlycemic Load Diet with a Unique Macronutrient Composition.” Metabol Synd and Related Disord 1:199208 – (2003).
24. Bell, S.J. and Sears, B. “The Zone Diet: An AntiInflammatory, Low GlycemicLoad Diet.” Metabol Synd and Related Disord 2:2438 – (2004).
25. Johnston, C.S., Tjonn, S., Swan, P.D., White A., Hutchins H., and Sears B. “Ketogenic lowcarbohydrate diets have no metabolic advantage over nonketogenic lowcarbohydrate diets.” Am J Clin Nutr 83: 10551061 – (2006)
26. Johnston CS, Tjonn SL, Swan PD, White A, and Sears B. “Lowcarbohydrate, Highprotein diets that restrict potassiumrich fruits and vegetables promote calciuria.” Osteoporos Int 17: 18201821 – (2006)
27. Johnston, C.S., White A.M, Tjonn, S., Swan P.D., Hutchins H., and Sears B. “Ketogenic lowcarbohydrate diets have no metabolic advantage over nonketogenic lowcarbohydrate diets. Reply to NJ Krilanovich.” Am J Clin Nutr 85: 239 – (2007)
28. Sorgi PJ, Hallowell EM, Hutchins HL, and Sears B. “Effects of an openlabel pilot study with highdose EPA/DHA concentrates on plasma phospholipids and behavior in children with attention deficit hyperactivity disorder Nutr J 13:16 – (2007)
29. White AM, Johnston CS, Swan PD, Tjonn SL, and Sears B. “Blood ketones are directly related to fatigue and
perceived effort during exercise in overweight adults adhering to low-carbohydrate diets for weight loss:
A pilot study.” J Am Diet Assoc 107: 1792-1796 (2007)
30. Sears B. “Anti-inflammatory diets for obesity and diabetes.” J Coll Amer Nutr 28: 482S-491S (2009)
31. Mills JD, Bailes JE, Sedney CL, Hutchins H, and Sears B. “Omega-3 dietary supplementation reduces traumaticaxonal injury in a rodent head injury model”. J Neurosurgery
32.  Sears B and Ricordi C.  “Anti-inflammatory nutrition as a pharmacological approach to treat obesity.” J Obesity 2011: 431985 (2011)
33.  Sears B and Ricordi C.  “Role of fatty acids and polyphenols in inflammatory gene transcription and their impact on obesity, metabolic syndrome, and diabetes.”  Eur Rev Med Pharmacol Sci 16: 1137-1154 (2012)
34.  Lorich, FE, Sears, B, and McNamara RK.  “Elevated ratio of arachidonic acid to long-chain omega-3 fatty acids predicts depression development following interferon-alpha treatment: Relationship with interleukin-6.”  Brain, Behavior, and Immunity Volume 31, July 2013, Pages 48–53 (2013)